1 proc soc exp biol med 1951 dec783702 3 effect of rabies street virus in the cotton rat and the swiss albino mouse reagan rl brueckner al. Effect of rabies virus infection on gene expression in mouse brain mikhail prosniak d craig hooper bernhard dietzschold and hilary koprowski center for neurovirology department of microbiology and immunology thomas jefferson university 1020 locust street philadelphia pa 19107 6799 contributed by hilary koprowski december 28 2000. Embryonic tissues from infected eggs will have a titer of about 105 for mice ic infected chick embryos die immediately before or at time of hatching reported to be nonpathogenic in dogs used as a live virus vaccine for canine immunization as it induces immunity in dogs effect on host. Rabies virus enters peripheral nerves or may replicate in myocytes and spread to motor nerve endings retrograde intra axonal centripetal spread to the cns occurs in peripheral nerves virus replicates in spinal cord neurons and spreads rapidly thruout the nervous system causing progressive lower motor neuron paralysis. These findings demonstrate the robustness of viral rna compared to viable virus or antigen in a decomposing animal supporting previous recommendations for the use of pcr based confirmatory testing in the diagnosis of rabies heaton et al 1997 david et al 2002 araujo et al 2008surprisingly rabies viral rna was detected in the decomposed mouse carcase at least 70 days maximum
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