The book begins by reviewing the historical experiments that led to the concept of a barrier protecting the brain from variations in the blood transport kinetics and carrier mediated processes are described and the mechanism by which molecules can cross the barrier is discussed. The brain is the only organ known to have its own security system a network of blood vessels that allows the entry of essential nutrients while blocking other substances unfortunately this barrier is so effective at protecting against the passage of foreign substances that it often prevents life . An introduction to the blood brain barrier excellent introduction to the phenomenology of blood brain barrier transport an understand ing of which is an obligatory first . The blood brain barrier serves to protect the brain from toxic substances whilst simultaneously allowing access to essential nutrients and chemical signals at the interface between brain and body knowledge of the blood brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. The blood brain barrier bbb is a highly selective semipermeable border that separates the circulating blood from the brain and extracellular fluid in the central nervous system cns the blood brain barrier is formed by endothelial cells of the capillary wall astrocyte end feet ensheathing the capillary and pericytes embedded in the capillary basement membrane
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